How DNA Testing Can Help Prevent and Manage Shingles

Shingles Awareness Week in Singapore is held annually, and in 2024 it took place from 26 February to 3 March. GSK launched a campaign, called Stop Shingles, to educate people about shingles, including the importance of prevention and asking a doctor or pharmacist about it. Activities include health forums and working with celebrities to encourage adults to speak with their healthcare providers.

In Singapore, it is estimated that 80 to 85% of adults would have had chicken pox, and 20% of these people would then later develop Shingles. Singapore is estimated to have about 30,000 new cases of Shingles each year.

GSK Shingles Awareness Week Poster 2024
Photo: GSK Stop Singles Campaign

What is Shingles?

Shingles, or herpes zoster, is a painful skin rash caused by the reactivation of the varicella-zoster virus (VZV), the same virus responsible for chickenpox. While the condition can affect anyone who has had chickenpox, some individuals are at higher risk due to genetic predispositions, weakened immune systems, or other health factors. Advances in DNA testing now offer insights into how individuals can manage and even prevent shingles by understanding their genetic makeup.

The Role of Genetics in Shingles Susceptibility

Research has shown that genetic factors can influence an individual’s immune response to the varicella-zoster virus. DNA testing can identify variations in immune system-related genes that may affect the ability to suppress the virus. For instance, specific genetic markers associated with weaker immune responses can signal a higher risk of shingles. Armed with this knowledge, individuals can take proactive steps to boost their immunity and reduce the likelihood of experiencing an outbreak.

Shingles Doctor Checkup
Photo: National Council on Aging

How DNA Testing Works for Shingles

DNA testing involves analysing a person’s genetic information to uncover predispositions to various health conditions, including shingles. The process includes:

  1. Sample Collection
    Typically, a saliva or cheek swab sample is collected.

  2. Genetic Analysis
    The sample is processed to identify gene variations related to immune function.

  3. Personalised Insights
    The results provide insights into your genetic risk for shingles and suggest preventative measures tailored to your genetic profile.

Preventive Strategies Based on DNA Testing

If a DNA test reveals a higher genetic risk for shingles, individuals can adopt the following strategies to reduce their risk:

  • Vaccination
    The shingles vaccine (e.g., Shingrix) effectively prevents the condition, especially for those at higher risk.

  • Immune-Boosting Lifestyle
    Maintaining a healthy diet, exercising regularly, managing stress, and getting adequate sleep can strengthen the immune system.

  • Antiviral Medications: In some cases, doctors may recommend antiviral medications as a preventive measure for high-risk individuals.

 

Managing Shingles with DNA Insights

For individuals who develop shingles, understanding their genetic predisposition can inform better management of the condition:

  • Personalised Treatment
    Genetic insights can help healthcare providers choose the most effective antiviral medications and pain management strategies.

  • Risk of Postherpetic Neuralgia (PHN)
    DNA testing can also indicate the likelihood of developing complications like PHN, a long-lasting pain condition. Early intervention can minimise the severity of PHN.
Shingles
Photo: National Skin Centre

Benefits of DNA Testing for Shingles

  1. Proactive Health Management
    DNA testing empowers individuals to make informed decisions about their health.

  2. Tailored Preventive Measures
    By understanding genetic risks, people can adopt lifestyle changes and medical interventions that are most effective for them.

  3. Enhanced Medical Care
    Doctors can provide personalised treatment plans based on genetic insights, improving outcomes for shingles patients.

 

Who Should Consider DNA Testing for Shingles?

  • Individuals Over 50
    The risk of shingles increases with age, making DNA testing particularly relevant for older adults.

  • Those with Family History
    A family history of shingles or related conditions may indicate a higher genetic risk.

  • Immunocompromised Individuals
    People with weakened immune systems due to chronic illnesses or medications can benefit from understanding their genetic predispositions.

To summarise…

DNA testing offers a powerful tool for preventing and managing shingles by uncovering genetic risks and enabling personalised health strategies. Companies like Genoplan and other DNA testing providers can help individuals take control of their health by offering insights into their genetic makeup. Whether through vaccination, lifestyle adjustments, or personalised medical care, leveraging DNA information ensures a proactive approach to shingles and overall well-being.

By understanding your genetic profile, you can take the necessary steps to reduce the impact of shingles and live a healthier, more informed life.

Unlock the secrets of your DNA • Discover yourself at a genetic level
Understand your health predispositions and take control • Live a longer and healthier life