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Peakspan and DNA: how knowing your genetic blueprint can help you plan to stay at your best

By Andre Ling, Co-Founder, MyDNA

Most of us know the first two words in the longevity conversation. Lifespan is how long you live. Healthspan is how long you live without serious illness.

There is now a third one, and it asks a sharper question: how long do you stay close to your best?

That is peakspan, and it has gone from a research paper to a talking point in a matter of months. This article covers what it means and what a DNA test can honestly tell you about it.

What is peakspan?

Peakspan is the number of years you keep at least 90% of your own peak performance in a particular physical or mental function, such as aerobic fitness or fast thinking. It was proposed in 2026 by Alex Zhavoronkov, Kejun Ying and Dominika Wilczok in Aging and Disease (DOI 10.14336/AD.2026.0080). It is a framework, not a clinical test.

Diagram of a performance curve with a dashed line at 90% of peak; the years above the line are shaded as peakspan

Two ideas sit behind it.

Most body systems peak early. The authors argue that many functions, including cardiovascular fitness, muscle strength and certain kinds of thinking, reach their best in your 20s or 30s and then ease off gradually. That happens in people who are perfectly healthy by any medical measure.

It is measured one function at a time. Your fitness peakspan and your memory peakspan are separate things. There is no single peakspan score for the whole of you.

The peakspan-healthspan gap

Timeline showing some functions pass 90% of peak by about age 50 while 20 or more healthy years remain

The authors call the space between the two the peakspan-healthspan gap. Their estimate is that by 50, a healthy person has likely moved past the 90% line for most functions, including fast thinking, aerobic capacity and lung function, while still having 20 or more healthy years ahead. It shows up in ordinary ways long before any diagnosis: slower reactions, less endurance, catching infections more easily.

That gap between “not ill” and “still at your best” is why the idea has caught on. Healthspan can look fine while strength, stamina, sleep or sharpness change gradually.

When different functions peak

Chart of the ages when thinking speed, memory, fitness, strength and vocabulary peak, from the 20s to the 50s

According to the authors’ review of published studies:

  • Fast, flexible thinking (processing speed, spatial reasoning) peaks at around 20 to 24. Working memory peaks a little later, at 25 to 29.
  • Experience-based abilities such as vocabulary and verbal comprehension peak much later, at around 45 to 54, and stay stable into the early 70s.
  • Aerobic fitness (the most oxygen your body can use during hard effort) peaks from the late teens to the mid-20s, then declines by about 10% a decade.
  • Muscle strength peaks between 20 and 35, holds fairly steady until about 50, and declines more noticeably from around 65.

So not everything peaks early. What you know and how well you use it keeps growing long after your sprint speed has gone.

A fair note on how new this is

Peakspan is a proposed framework, not an established clinical test. The 90% line was chosen by the authors, and the paper pulls together existing research rather than reporting a new study that follows people over decades. The lead author is affiliated with a longevity biotech company, which the paper declares. It is a useful way to think about ageing. It is not yet a number your doctor will measure.

What a DNA test cannot do

Claims online get loose at this point, so to be direct:

  • A DNA test cannot tell you your peakspan, or when any of your functions will start to decline.
  • It does not measure how fit, strong or sharp you are today. Your genes do not change, so the report is not a health check.
  • It is not a medical test or a health screening. It shows predisposition, which means likelihood, not certainty.

Genetics accounts for roughly 30% of health outcomes. The other 70% is what you do with it. A DNA test helps with that 30%, and it helps most by making the 70% more targeted.

Where a DNA test does help

The paper itself notes that genetics, sex and lifestyle all shape both how high your peak is and how quickly you move away from it. The reports in the MyDNA DNA Test, which comes with a personal consultation, cover areas that relate to several of these functions, such as fitness, sleep and nutrition.

1. Movement, strength and recovery

A woman holds a push-up position in a bright fitness studio during a strength session

Your genes influence how you respond to different kinds of exercise. The fitness reports include Muscular growth, Lower body strength, Explosive strength, Muscular endurance, Cardiovascular endurance, Heart rate recovery and Flexibility. There are also reports on tendon and joint injury, including Rotator cuff injury, ACL injury, Achilles tendon injury and Ankle injury.

Why it matters for peakspan: strength and cardiovascular fitness are two of the functions the peakspan authors discuss. Knowing whether your body leans towards endurance or power, and where you may be more prone to strain, helps you build a programme that keeps you training consistently instead of repeatedly starting over after an injury.

2. Sleep

A woman sleeps peacefully in a softly lit bedroom

Sleep is where the body repairs itself, and people differ a great deal in how they sleep. The sleep reports cover Deep sleep, Sleep latency, Insomnia, Excessive sleepiness, Daytime nap and Circadian rhythm.

If your results show a tendency towards lighter sleep or a later body clock, a good plan works with that, with timing, light, caffeine and wind-down habits set around how you are wired.

3. Nutrition and how your body handles it

A colourful spread of fresh vegetables, herbs and fruit on a wooden table

This is the area many people find most useful, because food is something you decide on three times a day. The reports include genetic tendencies around Vitamin D level, Vitamin B12 level, Folate level, Magnesium level, Iron level, DHA level, EPA level and Caffeine metabolism. Weight and diet reports cover Resting metabolic rate, High fat diet response, High protein diet response and Calorie restriction diet response.

These are tendencies, not blood tests. They tell you where your body may need more attention, so your consultant can suggest where to focus, and where a blood test may be worth asking about.

4. Metabolism and heart health

Triglyceride level, LDL cholesterol level, HDL cholesterol level and Insulin resistance sit alongside reports on blood pressure and circulation. Knowing your predisposition early gives you time to act on diet, movement, nutritional support and regular check-ups, well before anything becomes a concern.

5. Brain, memory and ageing

The reports include Aging and memory, Exercise and memory improvement, Long-term memory, Aging lung function and Telomere length and aging. For skin, there are Skin elasticity, Photoaging and Glycation and aging.

None of these predicts what will happen to you. They show where your genes lean, and they give you a reason to put the habits that support brain, lung and skin health at the top of your list.

From results to a plan

A consultant writing notes in a planner beside a tablet while a client looks on, going through next steps together

A report on its own is a long document. What matters is turning it into a handful of changes you will actually keep.

With MyDNA, that is built in:

  1. A consultant collects your sample in person, at your home, office or another convenient place in Singapore, and makes sure it is done correctly.
  2. Your results arrive in 10 to 14 days in a secure online account.
  3. Your consultant walks you through the findings and builds a personalised plan around food, movement, sleep and recovery, with nutritional support where your report and goals point to it. The consultation is included with the kit, with no separate fee.
  4. A Nutrition Scan gives you a snapshot of your nutritional status today. Your DNA shows your tendencies, and the scan shows where you are now on the nutrition side.

Because the plan comes from your own report, it replaces generic advice with priorities that fit you.

The baseline problem

Peakspan measures how far you are from your own best. Almost nobody has numbers from their 20s to compare against, and the authors acknowledge that measurements vary between studies and are hard to line up against a single peak.

So there is no point trying to reconstruct the past. Start from today:

  • Your DNA report shows the tendencies you were born with, and those do not change.
  • A Nutrition Scan gives a snapshot of your nutritional status today. It does not measure fitness, strength or thinking.
  • Your consultation turns both into a few priorities.
  • Repeating the basics over time, such as regular check-ups with your doctor, simple fitness tests or a wearable, gives you your own trend line.

Starting a baseline now gives you something to compare against next year.

Diagram with a Today marker; to the right, DNA report, Nutrition Scan and check-ups build your own trend line

Does it make sense to test at midlife?

Yes. Your DNA does not change, so there is no “too late” for the information itself. If you are in your 40s, 50s or beyond, the useful question is which areas deserve your effort from here.

Nobody can promise that a particular habit will restore or extend a function. The research on peakspan is early, and the authors say as much. What a personalised plan can do is point your effort in the right direction.

Your genetics are a blueprint, not your destiny.

Ready to find out how you are wired?

Explore the MyDNA DNA Test, or talk to a consultant. Helix, our assistant, takes a few details first and then connects you with the team.

Source: Zhavoronkov A, Ying K, Wilczok D. Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan. Aging and Disease, 2026. DOI 10.14336/AD.2026.0080.
MyDNA provides direct-to-consumer genetic testing for wellness and informational purposes. It is not a medical diagnostic test and does not replace medical advice, diagnosis, health screening or treatment. Genetic predisposition indicates likelihood, not certainty. Always consult a qualified healthcare professional about your personal health, and before starting any supplement, particularly if you are pregnant, have an existing condition, or take prescribed medication.